Here is a longtime Christmas favorite -- Domenico Ghirlandaio's Adoration of the Magi, 1488. I especially like the angels, and the musical notes, near the top. -- Adoration of the Magi.
(Here's a close-up of the angels.)
(And here are many more details from the painting.)
Note: This painting is more than nine feet tall! and approximately 8 feet wide.